ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-TETRAHYDROALSTONINE, (+)-ACRICINE, AND (+)-RESERPININE

Article abstract of DOI:10.1016/S0040-4039(00)94677-X

Starting from (-)β-ketoester 1a the preparation of (+)-elenoic acid 4a and (+)-isoelenoic acid 5a is described.Standard operations transform 5a into (+)-tetrahydroalstonine 7a, (+)-acricine 7b, and (+)-reserpinine 7c.