Alkylation of the cyclic sulfamate of prolinol. Preparation of optically active 2-alkyl-substituted pyrrolidines

Article abstract of DOI:10.1016/S0040-4039(00)61082-1

Treatment of the cyclic sulfamate of (R)-prolinol (1) with aromatic lithium reagents, followed by acidic hydrolysis, gives 2-substituted pyrrolidines 3a-c in moderate yields.