Synthesis and biological activity of 17-chloro-16(17) unsaturated D-homo antiprogestins

DOI: 10.1016/0039-128X(94)90024-8

Source and publish data:

Steroids p. 176 - 180 (1994)

Update date:2022-07-29

Topics:

Authors:

Schwede, Wolfgang

Cleve, Arwed

Neef, Guenter

Ottow, Eckhard

Stoeckemann, Klaus

Wiechert, Rudolf

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Article abstract of DOI:10.1016/0039-128X(94)90024-8

An efficient approach to 17-chloro-16(17) unsaturated D-homo antiprogestins is described.The key steps of the synthesis are a ring-expansion via dichlorocarbene addition to a 17-silyl enol ether and a palladium catalyzed coupling of an 11β-(4-aryltriflate

Full text of DOI:10.1016/0039-128X(94)90024-8

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