A general method for the preparation of benzylic α,α-difluorophosphonic acids; non-hydrolyzable mimemtics of phosphotyrosine

Article abstract of DOI:10.1016/S0040-4039(00)74672-7

Methodology is presented for the preparation of heretofore unreported benzylic α,α-difluorophosphonic acids. Oxidation of benzylic α-hydroxyphosphonates using MnO₂, provided a new route for the synthesis of benzylic α-oxophosphonates, which wer