Synthese, etude theorique et evaluation biologique de derives du 4-amino-4H-1,2,4-triazole analogues des antibiotiques β-lactamiques

Article abstract of DOI:10.1016/0223-5234(92)90003-J

The synthesis of three classes of potential antibiotic compounds derived from 4-amino-4H-1,2,4-triazole and related to β-lactam antibiotics is described.Their originality belongs to the replacement of the β-lactam carbonyl moiety by another electrophilic