Mixed Anhydrides in Peptide Synthesis. Reduction of Urethane Formation and Racemization Using N-Methylpiperidine as the Tertiary Amine Base

DOI: 10.1021/jo00165a036

Source and publish data:

Journal of Organic Chemistry p. 2939 - 2941 (1983)

Update date:2022-07-30

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Authors:

Chen, Francis M. F.

Steinauer, Rene

Benoiton, N. Leo

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Article abstract of DOI:10.1021/jo00165a036

The side reactions of urethane formation and racemization accompanying couplings by the mixed anhydride method are reduced when N-methylpiperidine is used as base, the best results being achieved in dichloromethane.

Full text of DOI:10.1021/jo00165a036

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