Mixed Anhydrides in Peptide Synthesis. Reduction of Urethane Formation and Racemization Using N-Methylpiperidine as the Tertiary Amine Base

DOI: 10.1021/jo00165a036

Source and publish data:

Journal of Organic Chemistry p. 2939 - 2941 (1983)

Update date:2022-07-30

Topics:

Authors:

Chen, Francis M. F.

Steinauer, Rene

Benoiton, N. Leo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00165a036

The side reactions of urethane formation and racemization accompanying couplings by the mixed anhydride method are reduced when N-methylpiperidine is used as base, the best results being achieved in dichloromethane.

Full text of DOI:10.1021/jo00165a036

Products guided by the article

Product name:6-Benzyloxycarbonylamino-2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-hexanoic acid methyl ester

Cas No:1437-02-1

R&D Labs maybe for 1437-02-1

Zhangjiagang Jianing Import & Export Co.,Ltd.

Contact:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
Tangshan Moneide Trading Co., Ltd.

Contact:+86-315-8309571

Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Jiangsu Willing Bio-Tech Co ltd

website:http://www.willingbio.com/

Contact:+86 18796908173

Address:No 18 Guoqiao Road
SPE Chemicals Co.,Ltd

Contact:

Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District

Relevant to this article

A New Oxidative Se-Dealkylation in Seleno-Pummerer Reaction of 1,8-Bis(methylseleno)naphthalene and Naphtho<1,8-b,c>-1,5-diselenocin Induced by Peri-Selenium Participation

Doi:10.1246/cl.1992.1437
(1992)
THE STRUCTURES AND STEREOCHEMISTRY OF CYTOTOXIC SESQUITERPENE QUINONES FROM DACTYLOSPONGIA ELEGANS

Doi:10.1016/S0040-4020(01)80012-0
(1992)
Pyrrolobenzodiazepines and related systems. 2. Synthesis and biological properties of isonoraptazepine derivatives

Doi:10.1021/jm00102a004
(1992)
Chelation-directed C-H activation/C-C bond forming reactions catalyzed by Pd(II) nanoparticles supported on multiwalled carbon nanotubes

Doi:10.1039/c7cc02122d
(2017)
Cation-Anion Combination Reactions. 19. Some Reactions of Ortho-Substituted Triarylmethyl Cations in Water

Doi:10.1021/jo00322a055
(1981)
New Aspects in the Reaction of Azomethines with Cyclic CH-Acidic Compounds

Doi:10.1007/BF00816851
(1992)

Article Doi