Adenosine Deaminase Inhibitors. Synthesis and Biological Evaluation of C1' and Nor-C1' Derivatives of (+)-erythro-9-(2(S)-Hydroxy-3(R)-nonyl)adenine

Article abstract of DOI:10.1021/jm00100a025

The synthesis of various chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine, (+)-EHNA, from (2S,3R)-3-amino-1,2-O-isopropylidene-1,2-nonanediol by condensation with 5-amino-4,6-dichloropyrimidine is described.The compounds synthesized were C1'