Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol

DOI: 10.1021/jm00099a002

Source and publish data:

Journal of Medicinal Chemistry p. 3731 - 3744 (1992)

Update date:2022-08-04

Topics:

Authors:

Finke Finke

Shah Shah

Ashe Ashe

Ball Ball

Blacklock

Bonney Bonney

Brause Brause

Chandler

Cotton Cotton

Davies Davies

Dellea Dellea

Dorn Jr.

Fletcher

O'Grady O'Grady

Hagmann Hagmann

Hand Hand

Knight Knight

Maycock Maycock

Mumford Mumford

et al. et al.

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Article abstract of DOI:10.1021/jm00099a002

Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of our previously reported cephalosporin-based HLE inhibitors has led to the identification of a s

Full text of DOI:10.1021/jm00099a002

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