Bioorganic and Medicinal Chemistry Letters p. 1947 - 1950 (2002)
Update date:2022-08-04
Topics:
Kimura, Makoto
Masuda, Tomoko
Yamada, Koji
Kubota, Nobuo
Kawakatsu, Nobuyuki
Mitani, Masaki
Kishii, Kenichi
Inazu, Masato
Namiki, Takayuki
Two types of novel diphenylalkyl piperazine derivatives containing the thio or aminopropanol moiety substituted by phenyl or benzyl group were synthesized, and evaluated for their calcium antagonistic and antioxidative activities. These compounds showed apparent inhibitions against KCl-induced contractions in isolated rat aorta. Among them, phenylamino compound 9 and benzylamino compound 13 also possessed potent inhibitory activities against auto-oxidative lipid peroxidations in canine brain homogenates. Two representative compounds 3a and 9 were evaluated for their inhibitory activities against KCl-induced contractions in isolated canine arteries (basilar, coronary, mesenteric, and renal). Both compounds showed the most potent inhibitions to basilar artery.
View MoreZhejiang Sanmei Chemical Industry Co., Ltd
Contact:86-579-87633213
Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
Hangzhou innopharma technology Co,.Ltd.(expird)
Contact:+86-13388601988
Address:Room845,lixin building, moganshan road, hangzhou, china
Changsha Huajing Powdery Material Technological Co., Ltd.
Contact:86-731-88879686
Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China
website:http://www.truewingroup.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)
Contact:051989185693
Address:NO 217 huangshan Rd ,Changzhou
Doi:10.1021/jo00049a018
(1992)Doi:10.1016/j.bmc.2013.01.068
(2013)Doi:10.1016/S0040-4020(01)89845-8
(1992)Doi:10.1080/10426507.2012.743134
(2013)Doi:10.1080/00021369.1982.10865536
(1982)Doi:10.1021/jo400433m
(2013)