Enantioselective synthesis of 2,2-dialkyltetrahydropyran-3-ones via the asymmetric Michael addition reaction using chiral imines

DOI: 10.1016/S0957-4166(00)82185-0

Source and publish data:

Tetrahedron Asymmetry p. 863 - 866 (1992)

Update date:2022-09-26

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Authors:

Desmaele

Pain Pain

D'Angelo

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Article abstract of DOI:10.1016/S0957-4166(00)82185-0

Addition of chiral imine 8 derived from 2-methyltetrahydropyran-3-one 7 and R-(+)-1-phenylethylamine, to methyl acrylate led to adduct (S)-9 with a good yield and an excellent stereoselectivity.

Full text of DOI:10.1016/S0957-4166(00)82185-0

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Product name:Benzenemethanamine, N-(dihydro-2-methyl-2H-pyran-3(4H)-ylidene)-a-methyl-

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