Highly enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones with simple Cu(II)-oxazoline-imidazoline catalysts

Article abstract of DOI:10.1016/j.tet.2013.04.063

A series of novel chiral ligands L1-L4 with an imidazoline-oxazoline framework have been developed as new type of non-symmetric N,N-bidentate ligands. All the chiral ligands were prepared from 2,2-diethylmalonic acid and enantiomerically pure (S)-2-amino-