Stereoselective synthesis of β-hydroxy-α-amino acids from chiral cyanohydrins

Article abstract of DOI:10.1016/S0957-4166(00)80518-2

An efficient one-pot reduction-transimination-hydrocyanation synthesis of β-hydroxy-α-cyanoamines 3 from optically active O-protected mandelonitrile (1) is described. These β-hydroxy-α-cyanoamines were easily converted into optically active (2S,3R) β-hydr