Synthesis of isatin 3-oximes from 2-nitroacetanilides

DOI: 10.1055/s-1992-26223

Source and publish data:

Synthesis p. 769 - 772 (1992)

Update date:2022-09-26

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Authors:

Kearney Kearney

Harris Harris

Jackson Jackson

Joule Joule

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Article abstract of DOI:10.1055/s-1992-26223

2-Nitroacetanilides, prepared by alkaline hydrolysis of 1-arylamino-1-methylthio-2-nitroethenes, are converted into isatin (1H-indole-2,3-dione) 3-oximes by treatment with concentrated sulfuric acid or trifluoromethanesulfonic acid at room temperature.

Full text of DOI:10.1055/s-1992-26223

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