The Phospha-Cope Rearrangement of 3-Phospha-1,5-hexadiene Derivatives Bearing a Hydroxyl Group

Article abstract of DOI:10.1246/cl.1992.1607

The title phospha-Cope rearrangement gives the corresponding cyclic phosphonates or phosphinates in 30 to 100percent yield.Stugies on solvent effects and kinetic isotope effects using the deuterated derivatives strongly support that there is a pre-equilibrium between tetracoordinate and pentacoordinate structures, followed by the rate-determinig phospha-Cope rearrangement.