Synthesis, Ligand Binding, and QSAR (CoMFA and Classical) Study of 3β-(3'-Substituted phenyl)-, 3β-(4'-substituted phenyl)-, and 3β-(3',4'-Disubstituted phenyl)tropane-2β-carboxylic Acids Methyl Esters

DOI: 10.1021/jm00044a007

Source and publish data:

Journal of Medicinal Chemistry p. 2865 - 2873 (1994)

Update date:2022-08-03

Topics:

Authors:

Carroll, F. Ivy

Mascarella, S. Wayne

Kuzemko, Michael A.

Gao, Yigong

Abraham, Philip

et al. et al.

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Article abstract of DOI:10.1021/jm00044a007

Several new 3β-(4'-substituted phenyl), 3β-(3'-substituted phenyl), and 3β-(3',4'-disubstituted phenyl)tropane-2β-carboxylic acid methyl esters were prepared and assayed for inhibition of <³H>WIN 35,428 binding to the dopamine transporter.The 3

Full text of DOI:10.1021/jm00044a007

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