Synthesis, Ligand Binding, and QSAR (CoMFA and Classical) Study of 3β-(3'-Substituted phenyl)-, 3β-(4'-substituted phenyl)-, and 3β-(3',4'-Disubstituted phenyl)tropane-2β-carboxylic Acids Methyl Esters

Article abstract of DOI:10.1021/jm00044a007

Several new 3β-(4'-substituted phenyl), 3β-(3'-substituted phenyl), and 3β-(3',4'-disubstituted phenyl)tropane-2β-carboxylic acid methyl esters were prepared and assayed for inhibition of <³H>WIN 35,428 binding to the dopamine transporter.The 3