HMG-CoA Reductase Inhibitors: Design, Synthesis, and Biological Activity of Tetrahydroindazole-Substituted 3,5-Dihydroxy-6-heptenoic Acid Sodium Salts

Article abstract of DOI:10.1021/jm00075a024

Compounds comprising a series of 7-<2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-3,5-dihydroxy-6-heptenoic acid sodium salts (18) were synthesized and tested for their ability to inhibit HMG-CoA reductase in a partially purified enzyme preparati