HMG-CoA Reductase Inhibitors: Design, Synthesis, and Biological Activity of Tetrahydroindazole-Substituted 3,5-Dihydroxy-6-heptenoic Acid Sodium Salts

DOI: 10.1021/jm00075a024

Source and publish data:

Journal of Medicinal Chemistry p. 3674 - 3685 (1993)

Update date:2022-08-03

Topics:

Authors:

Connolly, Peter J.

Westin, Claudia D.

Loughney, Deborah A.

Minor, Lisa K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00075a024

Compounds comprising a series of 7-<2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-3,5-dihydroxy-6-heptenoic acid sodium salts (18) were synthesized and tested for their ability to inhibit HMG-CoA reductase in a partially purified enzyme preparati

Full text of DOI:10.1021/jm00075a024

Products guided by the article

Product name:2H-Indazole-3-carboxaldehyde, 2-(4-fluorophenyl)-4,5,6,7-tetrahydro-7-[(4-methoxyphenyl)methyl]-

Cas No:144148-21-0

R&D Labs maybe for 144148-21-0

Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong
Shanghai Pengkai Chemical Co.,Ltd

Contact:+86-21-60526671

Address:No.4226 Duzhuang Rd Minhang District Shanghai China
CHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD

website:http://www.fengrunhuagong.com

Contact:+86-536-7869976

Address:Changyi Coastal Economic Development Zone
NOVASYNCS CO., LTD

Contact:0512-63006287

Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan

Relevant to this article

Stereoselective synthesis of homo-apioneplanocin A as potential inhibitor of S-adenosylhomocysteine hydrolase

Doi:10.1080/15257770701493559
(2007)
The coordination chemistry of 1,4-diazepan-6-amine

Doi:10.1002/ejic.200500690
(2006)
REACTION OF 2,3-O-ISOPROPYLIDENERIBOFURANOSYLAMINE TOSYLATE WITH 4-METHYL-4-ISOTHIOCYANATO-2-PENTANONE

Doi:10.1007/BF00506293
(1984)
Iron(III) triflate-catalyzed one-pot synthesis of acetal-type protected cyanohydrins from carbonyl compounds

Doi:10.1016/j.tetlet.2006.04.106
(2006)
The cofactor Mg²⁺ - A key switch for effective continuous enzymatic production of GDP-mannose using recombinant GDP-mannose pyrophosphorylase

Doi:10.1016/S0008-6215(97)10095-7
(1997)
Synthesis and Preliminary Biologic Evaluation of 5-Substituted-2-(4-substituted phenyl)-1,3-Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors

Doi:10.1111/j.1747-0285.2012.01344.x
(2012)

Article Doi