HMG-CoA Reductase Inhibitors: Design, Synthesis, and Biological Activity of Tetrahydroindazole-Substituted 3,5-Dihydroxy-6-heptenoic Acid Sodium Salts

DOI: 10.1021/jm00075a024

Source and publish data:

Journal of Medicinal Chemistry p. 3674 - 3685 (1993)

Update date:2022-08-03

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Authors:

Connolly, Peter J.

Westin, Claudia D.

Loughney, Deborah A.

Minor, Lisa K.

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Article abstract of DOI:10.1021/jm00075a024

Compounds comprising a series of 7-<2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-3,5-dihydroxy-6-heptenoic acid sodium salts (18) were synthesized and tested for their ability to inhibit HMG-CoA reductase in a partially purified enzyme preparati

Full text of DOI:10.1021/jm00075a024

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