Diastereoselective Synthesis of β-Amino Esters by the Lewis Acid-Mediated Reaction of N-Tosyl Aldimines with Ketene Bis(trimethylsilyl) Acetals

DOI: 10.1246/cl.1992.1445

Source and publish data:

Chemistry Letters p. 1445 - 1448 (1992)

Update date:2022-08-05

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Authors:

Shimada, Shigeru

Saigo, Kazuhiko

Abe, Masanori

Sudo, Atsushi

Hasegawa, Masaki

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Article abstract of DOI:10.1246/cl.1992.1445

In the presence of titanium(IV) bromide, N-tosyl aldimines smoothly reacted with ketene bis(trimethylsilyl) acetals at low temperature, and upon esterification anti-β-amino esters were obtained selectively.

Full text of DOI:10.1246/cl.1992.1445

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