A concise stereoselective approach to β-Alkylaspartates from β-Lactams via [2 + 2] cycloaddition reaction of ketenes to glyoxylic ester-derived imines

Article abstract of DOI:10.1016/S0040-4039(00)61295-9

syn β-Alkyl aspartates were obtained with high stereoselectivities from cis 4-alkoxycarbonyl-β-lactams prepared via [2 + 2] cycloaddition reaction of monoalkylketenes and glyoxalate derived imines.