"Mixed Inhibitor-Prodrug" as a New Approach toward Systemically Active Inhibitors of Enkephalin-Degrading Enzymes

DOI: 10.1021/jm00091a016

Source and publish data:

Journal of Medicinal Chemistry p. 2473 - 2481 (1992)

Update date:2022-08-04

Topics:

Authors:

Fournie-Zaluski, Marie-Claude

Coric, Pascal

Turcaud, Serge

Lucas, Evelyne

Noble, Florence

et al. et al.

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Article abstract of DOI:10.1021/jm00091a016

In order to evaluate the possible advantages of potentiating the effects of the endogenous enkephalins, to obtain analgesia without the serious drawbacks of morphine, it was essential to design systemically active compounds which inhibit the two metaboliz

Full text of DOI:10.1021/jm00091a016

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