"Mixed Inhibitor-Prodrug" as a New Approach toward Systemically Active Inhibitors of Enkephalin-Degrading Enzymes

DOI: 10.1021/jm00091a016

Source and publish data:

Journal of Medicinal Chemistry p. 2473 - 2481 (1992)

Update date:2022-08-04

Topics:

Authors:

Fournie-Zaluski, Marie-Claude

Coric, Pascal

Turcaud, Serge

Lucas, Evelyne

Noble, Florence

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00091a016

In order to evaluate the possible advantages of potentiating the effects of the endogenous enkephalins, to obtain analgesia without the serious drawbacks of morphine, it was essential to design systemically active compounds which inhibit the two metaboliz

Full text of DOI:10.1021/jm00091a016

Products guided by the article

Product name:Benzenepropanoic acid, a-(mercaptomethyl)-, (R)-

Cas No:144489-76-9

R&D Labs maybe for 144489-76-9

Suzhou Health Chemicals Co., Ltd.

website:http://www.healthchems.com

Contact:13776257979

Address:No. 338, Jingang Avenue,
Shandong Dayi Chemical Co., Ltd.

website:http://www.dayi.com.cn

Contact:+86- 535-7388728. 15306386031

Address:No 1 Danya west road, Laiyang City, Shandong province
Wuhan Silworld Chemical Co.,Ltd

website:http://www.silworldchemical.com

Contact:+86-27-85613400

Address:No.198 jiangjun Road, Wuhan,China 430033
Zouping Mingxing Chemical Co.,Ltd.

website:http://www.zoutong.com.cn

Contact:86-543-2240068 2240067

Address:428 Daixi Third Road Zouping County Shandong Province China
Buffett (China) Holding Co.,Ltd

Contact:4006570891

Address:

Relevant to this article

First asymmetric synthesis of planar chiral [2.2]metacyclophanes

Doi:10.1039/c3cc42275e
(2013)
A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

Doi:10.1039/c2mb25347j
(2012)
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2

Doi:10.1016/j.bmcl.2013.05.054
(2013)
Facile three-component domino reactions for the synthesis of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines

Doi:10.1016/j.tetlet.2013.04.126
(2013)
Synthesis of the imidazole-derived AT₁-selective ANG II receptor antagonist HR 720 utilizing reductive amination as key step

Doi:10.1055/s-1996-4383
(1996)
Terminal alkylphosphanylidene organotantalum(V) complexes

Doi:10.1002/ejic.201300500
(2013)

Article Doi