Synthesis of the imidazole-derived AT1-selective ANG II receptor antagonist HR 720 utilizing reductive amination as key step

DOI: 10.1055/s-1996-4383

Source and publish data:

Synthesis p. 1325 - 1330 (1996)

Update date:2022-08-04

Topics:

Authors:

Heitsch, Holger

Wagner, Adalbert

Yadav-Bhatnagar, Neerja

Griffoul-Marteau, Christine

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1996-4383

The straightforward synthesis of the (1-methylbiphenylsulfonyl)urea substituted imidazole HR 720, an orally active ANG II receptor antagonist, by reductive amination of 2'-sulfonamidobiphenylcarbaldehydes, derived from Suzuki-type phenyl-phenyl coupling p

Full text of DOI:10.1055/s-1996-4383

Products guided by the article

Product name:1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-

Cas No:144628-52-4

R&D Labs maybe for 144628-52-4

Xinchang Jiu Xin Pharmaceutical Co., Ltd

website:http://www.jiuxinpharm.com

Contact:86 137 5756 8585

Address:Poyang industry Park
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Shuanghe Bio-Technology Limited(expird)

Contact:+86-571-61710758,18968016640

Address:Jinqiao north road 916# Fuyang
Luna Chemicals Co.,Ltd.

Contact:+86-570-4336358

Address:No.87 Building,Tianqian,Sidu Town
Shandong Hongxiang Zinc Co., Ltd

Contact:086-0311-66187879

Address:DaWang developing zone

Relevant to this article

An intramolecular heck approach to obtain 17-membered macrocyclic diversity and the identification of an antiangiogenesis agent from a zebrafish assay

Doi:10.1002/ejoc.201300408
(2013)
Doi:10.1021/jo00398a027
(1978)
Stereocontrolled total synthesis of polygalolide A

Doi:10.1002/asia.201300362
(2013)
Synthesis and structural determination of zinc complexes based on an anilido-aldimine ligand containing an O-donor pendant arm: Zinc alkoxide derivative as an efficient initiator for ring-opening polymerization of cyclic esters

Doi:10.1039/c3dt50756d
(2013)
Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents

Doi:10.1016/j.cclet.2013.05.009
(2013)
Doi:10.1007/BF00903570
(1966)

Article Doi