Synthesis of the imidazole-derived AT1-selective ANG II receptor antagonist HR 720 utilizing reductive amination as key step

DOI: 10.1055/s-1996-4383

Source and publish data:

Synthesis p. 1325 - 1330 (1996)

Update date:2022-08-04

Topics:

Authors:

Heitsch, Holger

Wagner, Adalbert

Yadav-Bhatnagar, Neerja

Griffoul-Marteau, Christine

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Article abstract of DOI:10.1055/s-1996-4383

The straightforward synthesis of the (1-methylbiphenylsulfonyl)urea substituted imidazole HR 720, an orally active ANG II receptor antagonist, by reductive amination of 2'-sulfonamidobiphenylcarbaldehydes, derived from Suzuki-type phenyl-phenyl coupling p

Full text of DOI:10.1055/s-1996-4383

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Product name:1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-

Cas No:144628-52-4

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