Journal of Organic Chemistry p. 6775 - 6781 (2013)
Update date:2022-07-29
Topics:
Donthiri, Ramachandra Reddy
Pappula, Venkatanarayana
Chandra Mohan, Darapaneni
Gaywala, Hiren H.
Adimurthy, Subbarayappa
In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. With 1 equiv of NaOH, N1,C5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N1,C5-dialkylated products through hydride ion transformation from alcohol.
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