Angewandte Chemie - International Edition p. 1727 - 1731 (2019)
Update date:2022-07-29
Topics:
Marcyk, Paul T.
Jefferies, Latisha R.
AbuSalim, Deyaa I.
Pink, Maren
Baik, Mu-Hyun
Cook, Silas P.
The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. Described herein is a simple iron-based catalyst system which provides the mild, direct conversion of secondary and tertiary alcohols to sulfonamides. Starting from enantioenriched alcohols, the intramolecular variant proceeds with stereoinversion to produce enantioenriched 2- and 2,2-subsituted pyrrolidines and indolines, without prior derivatization of the alcohol or solvolytic conditions.
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Doi:10.1016/S0040-4020(01)00788-8
(2001)Doi:10.1016/S0040-4039(00)92209-3
(1992)Doi:10.1021/jm00094a003
(1992)Doi:10.1016/S0040-4020(01)88497-0
(1992)Doi:10.1039/d0nj03002c
(2021)Doi:10.1021/jm00093a001
(1992)