A flexible, efficient synthesis of (±)-carbocyclic phosphonic acid nucleoside derivatives

DOI: 10.1055/s-2005-863745

Source and publish data:

Synlett p. 765 - 768 (2005)

Update date:2022-08-04

Topics:

Authors:

Wainwright, Phillip

Maddaford, Adrian

Bissell, Richard

Fisher, Ray

Leese, David

Lund, Andrew

Runcie, Karen

Dragovich, Peter S.

Gonzalez, Javier

Kung, Pei-Pei

Middleton, Donald S.

Pryde, David C.

Stephenson, Peter T.

Sutton, Scott C.

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Article abstract of DOI:10.1055/s-2005-863745

An efficient and flexible synthesis of cyclopentane and hydroxylated cyclopentane phosphonic acid analogues is described. The key step involves the opening of an epoxide with either a nucleoside base or a selenyl anion to access the target molecules.

Full text of DOI:10.1055/s-2005-863745

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