Total Synthesis of the Polyether Antibiotic Lysocellin. 2. Stereocontrolled Synthesis of the C10-C23 Fragment and Its Aldol Condensation with the C1-C9 Fragment to Complete the Total Synthesis of Lysocellin

Article abstract of DOI:10.1016/S0040-4039(00)61140-1

The C10-C23 ethyl ketone (4) was synthesized via coupling of the C16-C23 aldehyde (3) with the C11-C15 fragment (8), and subjected to the aldol reaction with the C1-C9 aldehyde (2) to complete the first stereoselective synthesis of the polyether antibioti