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In conclusion we designed and characterized new
inhibitor compounds with remarkable selectivity towards
CK1d and e.
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Acknowledgments The authors would like to thank Jacqueline
¨
biochemical parameters for chromatin and nuclear matrix
association of SV40 large T antigen in transformed cells.
Oncogene 1(2):119–129
Kru¨ger and Martin Stoter for excellent technical support. The authors
also thank CRELUX GmbH for the X-ray crystallographic analysis.
This work was supported by grants to Uwe Knippschild from the
Deutsche Krebshilfe (108489), Dr. Mildred Scheel Stiftung, and the
Deutsche Forschungsgemeinschaft (DFG) (KN356/6-1).
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Open Access This article is distributed under the terms of the
Creative Commons Attribution License which permits any use, dis-
tribution, and reproduction in any medium, provided the original
author(s) and the source are credited.
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