Tetrahedron Letters p. 4897 - 4900 (1992)
Update date:2022-08-03
Topics:
Viala, Jacques
Sandri, Jacqueline
Total stereospecific synthesis of EPA has been performed by a sequence of ozonolysis, selective reduction and Wittig reactions which affords the cis-skipped olefinic system.Versatile compound 4, readily prepared from dihydro anisole, allowed us to prepare the skipped dienic synthon 2 in high yield.Key Words: All cis-eicosapentanoic acid, EPA, cis-Wittig reaction, Ozonolysis.
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