SYNTHESIS AND PROPERTIES OF 1-ARYL-1,4-DIHYDRO-2,7-DIMETHYL-4-OXOPYRIDOPYRIMIDINE-6-CARBOXYLIC ACIDS AND THEIR DERIVATIVES

Article abstract of DOI:10.1007/BF00767010

Acetylation of 2-arylamino-5-carbethoxy-6-methylnicotinonitriles gave N-acetyl-2-arylamino-5-carbethoxy-6-methylnicotinonitriles, which, under the influence of hydrogen chloride, are cyclized to 1-aryl-1,4-dihydro-6-carbethoxy-2,7-dimethyl-4-oxopyrido<2,3-d>pyrimidines.The latter can be converted to the corresponding carboxylic and hydroxamic acids, as well as to acetylation products 1-aryl-2-acetonyl-1,4-dihydro-6-carbethoxy-7-methyl-4-oxopyrido<2,3-d>pyrimidines.