Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C-O bond cleavage

DOI: 10.1039/c3cc43616k

Source and publish data:

Chemical Communications p. 7794 - 7796 (2013)

Update date:2022-08-04

Topics:

Authors:

Luo, Shuang

Yu, Da-Gang

Zhu, Ru-Yi

Wang, Xin

Wang, Lei

Shi, Zhang-Jie

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Article abstract of DOI:10.1039/c3cc43616k

The first iron-catalyzed formal cross coupling of homobenzylic methyl ethers with alkyl Grignard reagents is realized. The reaction is proposed to proceed through a sequence of dehydroalkoxylation to form the vinyl-intermediate, followed by Fe-catalyzed selective carbometalation to form a benzylic Grignard reagent.

Full text of DOI:10.1039/c3cc43616k

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