Two Carbon Homologation of Carboxylic Acids via Carbon Radicals Generated from the Acyl Derivatives of N-Hydroxy-2-thiopyridone: Synthesis of Cn+2 α-Keto-acids from Cn Acids. (The 'Three carbon' Problem).

DOI: 10.1016/S0040-4039(00)61177-2

Source and publish data:

Tetrahedron Letters p. 5017 - 5020 (1992)

Update date:2022-07-30

Topics:

Authors:

Barton, Derek H. R.

Chern, Ching-Yuh

Jaszberenyi, Joseph Cs.

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Article abstract of DOI:10.1016/S0040-4039(00)61177-2

Reaction of olefins containing a three carbon atom chain with carbon radicals generated from carboxylic acids furnishes adducts that are precursors of the corresponding two carbon atom longer α-keto-acids.These keto-acids are furnished in high overall yield.

Full text of DOI:10.1016/S0040-4039(00)61177-2

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