Two Carbon Homologation of Carboxylic Acids via Carbon Radicals Generated from the Acyl Derivatives of N-Hydroxy-2-thiopyridone: Synthesis of Cn+2 α-Keto-acids from Cn Acids. (The 'Three carbon' Problem).

Article abstract of DOI:10.1016/S0040-4039(00)61177-2

Reaction of olefins containing a three carbon atom chain with carbon radicals generated from carboxylic acids furnishes adducts that are precursors of the corresponding two carbon atom longer α-keto-acids.These keto-acids are furnished in high overall yield.