Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein

DOI: 10.1248/cpb.40.1814

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1814 - 1817 (1992)

Update date:2022-08-05

Topics:

Authors:

Wanaka Wanaka

Okada Okada

Tsuda Tsuda

Okamoto Okamoto

Hijikata-Okunomiya

Okamoto Okamoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.1814

Based on studies of structure-activity relationship, trans-4-aminomethylcyclohexanecarbonyl-L-phenylalanine-4-carboxymethyl anilide (Tra-Phe-APAA) was designed as a selective plasma kallikrein inhibitor and synthesized. Tra-Phe-APAA inhibited plasma kalli

Full text of DOI:10.1248/cpb.40.1814

NII-Electronic Library Service

Products guided by the article

Product name:H-Tra-D-Phe-4-carboxymethylanilide

Cas No:145680-99-5

R&D Labs maybe for 145680-99-5

Daqing New Century Fine Chemical Co., Ltd.(expird)

Contact:010-57126694

Address:No.39, jinxing cun, honggang district
ZHEJIANG NHU COMPANY LTD.

Contact:86-575-86132822，86-575-86085355

Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
Valiant Fine Chemicals Co., Ltd.

Contact:+86 535 6101878/6374484

Address:11 Wuzhishan Rd.,YTETDZ,Yantai,264006,Shandong,China
Fuxin Jintelai Fluorin Chemical Co., Ltd.

Contact:+86-0418-8229599

Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China
xujianqiang

Contact:86-21-57725962

Address:shanghai

Relevant to this article

The Baylis-Hillman acetates in organic synthesis: Development of a facile strategy for synthesis of functionalized unsaturated benzo-fused macrocyclic ethers and [n] metacyclophanes

Doi:10.1039/c3ra40926k
(2013)
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y₁ receptor antagonists

Doi:10.1016/j.ejmech.2018.09.014
(2018)
Spontaneous dehydrogenation of 2-hydrazinoethyl- and 4-hydrazinobut-2- enylphosphonium salts

Doi:10.1007/s11172-012-0328-7
(2012)
Rigid organic nanotubes obtained from phenylene-butadiynylene macrocycles

Doi:10.1039/c3cc43177k
(2013)
Synthesis and biological evaluation of pyranoisoflavone derivatives as anti-inflammatory agents

Doi:10.1016/j.fitote.2014.06.002
(2014)
Doi:10.1016/S0020-1693(00)86835-8
(1992)

Article Doi