Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein

DOI: 10.1248/cpb.40.1814

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1814 - 1817 (1992)

Update date:2022-08-05

Topics:

Authors:

Wanaka Wanaka

Okada Okada

Tsuda Tsuda

Okamoto Okamoto

Hijikata-Okunomiya

Okamoto Okamoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.1814

Based on studies of structure-activity relationship, trans-4-aminomethylcyclohexanecarbonyl-L-phenylalanine-4-carboxymethyl anilide (Tra-Phe-APAA) was designed as a selective plasma kallikrein inhibitor and synthesized. Tra-Phe-APAA inhibited plasma kalli

Full text of DOI:10.1248/cpb.40.1814

NII-Electronic Library Service

Products guided by the article

Product name:H-Tra-D-Phe-4-carboxymethylanilide

Cas No:145680-99-5

R&D Labs maybe for 145680-99-5

Xi'an caijing Opto-Electrical Science & Technology Co., LTD

Contact:+86-29-88294447

Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Jewim Pharmaceutical (Shandong) Co., Ltd

Contact:+8615621883869

Address:山东省泰安市高新技术产业开发区配天门大街西首
Shanghai Rainbow Chemistry Co., Ltd.

Contact:+86-21-64968086-5815/5812

Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
Beijing eternalchem Co,. Ltd

Contact:+86-10-59484199

Address:No.58-A1026 Liangguan Street
NINGBO PANGS CHEM INT’L CO.,LTD.

Contact:+86-574-27666845

Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA

Relevant to this article

The Baylis-Hillman acetates in organic synthesis: Development of a facile strategy for synthesis of functionalized unsaturated benzo-fused macrocyclic ethers and [n] metacyclophanes

Doi:10.1039/c3ra40926k
(2013)
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y₁ receptor antagonists

Doi:10.1016/j.ejmech.2018.09.014
(2018)
Spontaneous dehydrogenation of 2-hydrazinoethyl- and 4-hydrazinobut-2- enylphosphonium salts

Doi:10.1007/s11172-012-0328-7
(2012)
Rigid organic nanotubes obtained from phenylene-butadiynylene macrocycles

Doi:10.1039/c3cc43177k
(2013)
Synthesis and biological evaluation of pyranoisoflavone derivatives as anti-inflammatory agents

Doi:10.1016/j.fitote.2014.06.002
(2014)
Doi:10.1016/S0020-1693(00)86835-8
(1992)

Article Doi