Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein

DOI: 10.1248/cpb.40.1814

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1814 - 1817 (1992)

Update date:2022-08-05

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Authors:

Wanaka Wanaka

Okada Okada

Tsuda Tsuda

Okamoto Okamoto

Hijikata-Okunomiya

Okamoto Okamoto

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Article abstract of DOI:10.1248/cpb.40.1814

Based on studies of structure-activity relationship, trans-4-aminomethylcyclohexanecarbonyl-L-phenylalanine-4-carboxymethyl anilide (Tra-Phe-APAA) was designed as a selective plasma kallikrein inhibitor and synthesized. Tra-Phe-APAA inhibited plasma kalli

Full text of DOI:10.1248/cpb.40.1814

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