New Type of Cyclization of α,β,χ,ψ-Unsaturated Dioic Acid Esters through Tandem Conjugate Additions by Using Lithium N-Benzyl-N-(trimethylsilyl)amide as a Nitrogen Nucleophile

DOI: 10.1021/jo00037a034

Source and publish data:

Journal of Organic Chemistry p. 3139 - 3145 (1992)

Update date:2022-08-04

Topics: Cyclization

Authors:

Uyehara, Tadao

Shida, Naomi

Yamamoto, Yoshinori

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Article abstract of DOI:10.1021/jo00037a034

Treatment of dimethyl (2E,6E)-2,6-octadienedioate with lithium N-benzyl-N-(trimethylsilyl)amide (LSA) gave 5-exo-trig ring closure products, methyl 3-(N-benzylamino)-2-(methoxycarbonyl)cyclopentane-1-acetates, through tandem conjugate additions.The relate

Full text of DOI:10.1021/jo00037a034

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