Enantiospecific Syntheses of α-(Fluoromethyl)tryptophan Analogues: Interactions with Tryptophan Hydroxylase and Aromatic L-Amino Acid Decarboxylase

DOI: 10.1021/jm00055a001

Source and publish data:

Journal of Medicinal Chemistry p. 305 - 313 (1993)

Update date:2022-08-04

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Authors:

Zembower, David E.

Gilbert, Judith A.

Ames, Matthew M.

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Article abstract of DOI:10.1021/jm00055a001

α-Fluoromethyl amino acids are enzyme-activated irreversible inhibitors of amino acid decarboxylases.Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the final step in the biosynthesis of both dopamine and serotonin via decarboxyla

Full text of DOI:10.1021/jm00055a001

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