Enantiospecific Syntheses of α-(Fluoromethyl)tryptophan Analogues: Interactions with Tryptophan Hydroxylase and Aromatic L-Amino Acid Decarboxylase

Article abstract of DOI:10.1021/jm00055a001

α-Fluoromethyl amino acids are enzyme-activated irreversible inhibitors of amino acid decarboxylases.Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the final step in the biosynthesis of both dopamine and serotonin via decarboxyla