Enantiospecific Syntheses of α-(Fluoromethyl)tryptophan Analogues: Interactions with Tryptophan Hydroxylase and Aromatic L-Amino Acid Decarboxylase

DOI: 10.1021/jm00055a001

Source and publish data:

Journal of Medicinal Chemistry p. 305 - 313 (1993)

Update date:2022-08-04

Topics:

Authors:

Zembower, David E.

Gilbert, Judith A.

Ames, Matthew M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00055a001

α-Fluoromethyl amino acids are enzyme-activated irreversible inhibitors of amino acid decarboxylases.Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the final step in the biosynthesis of both dopamine and serotonin via decarboxyla

Full text of DOI:10.1021/jm00055a001

Products guided by the article

Product name:dimethyl (2S,3aS,8aR)-8-5-methoxy-(phenylsulfonyl)-2-<<2-(trimethylsilyl)ethoxy>methyl>-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-1,2-dicarboxylate

Cas No:145919-17-1

R&D Labs maybe for 145919-17-1

Daqing New Century Fine Chemical Co., Ltd.(expird)

Contact:010-57126694

Address:No.39, jinxing cun, honggang district
Zhejiang Linhai Xinhua Chemicals Factory

Contact:0086-13661858911

Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Wuhan Better Organic Technology Inc.

Contact:13307163183

Address:Wuhan Economic&Technology Development Zone, Hubei
ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD

Contact:86-561-4080321

Address:No.8 Lieshan Industrial Zone of Huaibei
Aqua Chem Industry Co., Ltd

Contact:+86-515-88356562

Address:No.2, West Daqing Road, Yancheng, Jiangsu, China

Relevant to this article

Studies on organophosphorus compounds; LXIII. A new and facile synthetic route to protected phosphonodipeptides: A backbone for the formation of oligophosphonopeptides

Doi:10.1055/s-1992-26319
(1992)
Doi:10.1051/epjap:2001192
(1952)
Preparation of [3α-³H]3β-hydroxy-18β- and 3α-hydroxy-18(β and α)-glycyrrhetic acid and radioimmunoassay of glycyrrhetic acid

Doi:10.1248/cpb.36.3264
(1988)
Chiroptical Detection During Liquid Chromatography, Part 5: On-Line Measurement of Circular Dichroism Spectra Δε(λ) During Stops of Chromatographic Flow

Doi:10.1007/BF00810937
(1992)
Synthesis of 1,2,4-Triazoles and 1,2,4,6-Tetraazabicyclo[3.3.0]octanes from diphenyl cyanocarbonimidate. Competition between addition of hydrazines to esters or nitriles

Doi:10.1016/S0040-4020(01)80516-0
(1993)
Doi:10.1039/JR9650004194
()

Article Doi