Catecholamine-protein conjugates: Isolation of an adduct of N-acetylhistidine to the side chain of N-acetyldopamine from an insect-enzyme catalyzed reaction

Article abstract of DOI:10.1016/S0040-4039(00)92150-6

N^α-Acetyl-N ^τ-[1-(3,4,-dihydroxyphenyl)-2-N-acetylamino-ethyl]-histidine (4) was isolated from a biomimetic reaction containing N-acetyl-dopamine 1, N^α-acetyl-L-histidine and cuticle of silkmoth larvae as an enzyme source. The formation of 4 suggests an 1,6-addition of the N^τ imidazole nitrogen to the p-quinone methide 3.