Catalyst free, regioselective one-pot three-component synthesis of thiazol-2-imine derivatives in ionic liquid

Article abstract of DOI:10.1016/j.tetlet.2013.08.056

A one-pot three-component approach for the synthesis of thiazol-2-imines has been described by the reaction of amine, phenyl isothiocyanate and β-nitroacrylate in [Hbim]BF₄ ionic liquid. The method is applicable for aromatic, benzylic, aliphatic and cyclic amines. Reusable reaction media, regioselectivity, mild reaction condition, catalyst free and high yield of products are the salient features of this protocol.