Synthesis and biological activity of enantiomeric oxapenemcarboxylic acids

Article abstract of DOI:10.1055/s-1992-26329

The synthesis of enantiomerically pure potassium (5R)- and (5S)-trans-2-tert-butyl-6-hydroxymethyloxapenem-3-carboxylates is reported. Surprisingly, both enantiomers were active antibiotics and β-lactamase inhibitors.