Chemical and Pharmaceutical Bulletin p. 2399 - 2409 (1992)
Update date:2022-08-04
Topics:
Tsuji
Nakamura
Konishi
Okumura
Matsuo
Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinfiammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.
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Doi:10.1016/S0040-4039(00)60821-3
(1992)Doi:10.1016/S0040-4039(00)61009-2
(1992)Doi:10.1016/S0022-328X(98)00482-3
(1998)Doi:10.1016/0040-4039(93)85051-W
(1993)Doi:10.1016/j.carres.2013.07.008
(2013)Doi:10.1002/anie.201607752
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