Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxymethanesulfonanilide derivatives

DOI: 10.1248/cpb.40.2399

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2399 - 2409 (1992)

Update date:2022-08-04

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Authors:

Tsuji Tsuji

Nakamura

Konishi Konishi

Okumura Okumura

Matsuo Matsuo

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Article abstract of DOI:10.1248/cpb.40.2399

Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinfiammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.

Full text of DOI:10.1248/cpb.40.2399

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