Synthesis of thymidine dimer derivatives containing an amide linkage and their incorporation into oligodeoxyribonucleotides

Article abstract of DOI:10.1016/0040-4039(93)85051-W

The syntheses of thymidine dimers in which the natural phosphodiester linkage has been replaced by an amide group (3′-NR-CO-CH₂-5′; R=H, Me, n-Pr) are described. These new dimers were incorporated into oligonucleotides. Measurement of melting temperatures (T_m of DNA/RNA duplexes and the nuclease resistance are presented. Preliminary results of molecular mechanics calculations are included.