Conversion of N-acyl-2,3-dihydro-4-pyridones to 4-chloro-1,2-dihydropyridines using the Vilsmeier reagent

DOI: 10.1016/0040-4039(93)88003-2

Source and publish data:

Tetrahedron Letters p. 7635 - 7638 (1992)

Update date:2022-08-04

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Authors:

Al-Awar Al-Awar

Joseph Joseph

Comins Comins

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Article abstract of DOI:10.1016/0040-4039(93)88003-2

N-Acyl-2,3-dihydro-4-pyridones are converted to 1-acyl-4-chloro-1,2-dihydropyridines in one step using one equivalent of Vilsmeier reagent. This conversion was utilized in an asymmetric synthesis of (-)-coniine.

Full text of DOI:10.1016/0040-4039(93)88003-2

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