Protection of primary amino as pyrrole in organometallic reagents

DOI: 10.1016/S0040-4039(00)74737-X

Source and publish data:

Tetrahedron Letters p. 8125 - 8126 (1992)

Update date:2022-09-26

Topics:

Authors:

Davis Davis

Egan Egan

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Article abstract of DOI:10.1016/S0040-4039(00)74737-X

Pyrrole 5 was converted into Grignard and organocuprate reagents. After addition of the latter to alkene 6, the pyrrole ring was converted to a primary amine by ozonolysis, reduction and hydrolysis.

Full text of DOI:10.1016/S0040-4039(00)74737-X

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Product name:(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Diacetoxy-3-cyanomethyl-10,13-dimethyl-3-(4-pyrrol-1-ylmethyl-phenyl)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

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