Synthesis of Enantiomerically Pure (2R,5R) Disubstituted Pyrrolidines from D-Mannitol

DOI: 10.1016/S0040-4020(01)89042-6

Source and publish data:

Tetrahedron p. 10127 - 10132 (1992)

Update date:2022-07-31

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Authors:

Marzi, M.

Minetti, P.

Misiti, D.

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Article abstract of DOI:10.1016/S0040-4020(01)89042-6

Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form.Some comments and studies regarding pyrrolidine ring closure (key step) are also reported.

Full text of DOI:10.1016/S0040-4020(01)89042-6

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