Use of 2-trimethylsilylethyl as a protecting group in phosphate monoester synthesis

Article abstract of DOI:10.1016/0040-4039(93)88016-C

A model study has demonstrated that phosphorylation of a highly hindered hydroxyl group can be achieved via sequential treatment with (1) 2-trimethylsilylethyl dichlorophosphite, (2) 2-trimethylsilylethyl alcohol, and (3) hydrogen peroxide. The resulting