Thiophene as a structural element of physiologically active compounds, XX: A thiophene analogue of the leukotrien D4 antogonist Ro 23-3544

Article abstract of DOI:10.1002/ardp.19923251210

The synthesis of 6-Acetyl-7-[[5-(5-acetyl-4-hydroxy-3-propyl-2-thienyloxy)pentyl]oxy]-3 ,4-dihydro-2H-1-benzopyran-2-carboxylic acid (1), a thiophene analogue of the leukotrien antagonist Ro 23-3544, is described. Compound 1 shows almost no effect on leuc