Tetrahedron Asymmetry p. 121 - 131 (1993)
Update date:2022-08-04
Topics:
Herdeis, Claus
Luetsch, Karen
A stereoselective synthesis of the 4 stereoisomers of 2-methyl-4-hydroxy-5-amino-pentanoic acid namely 2R,4S-9a, 2S,4S-9b, ent-9a and ent-9b is presented, starting from the known lactones S-1 and R-1, which are readily avalaible from L- and D-glutamic acid.Only ent-9b shows affinity for GABAB-receptors sites.
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