Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b- hexahydro-3-propyl-1H-benz[e]indole-9-carboxamide: A potent and selective 5- HT(1A) receptor agonist with good oral availability

DOI: 10.1021/jm00067a018

Source and publish data:

Journal of Medicinal Chemistry p. 2208 - 2218 (1993)

Update date:2022-08-03

Topics:

Authors:

Lin Lin

Haadsma-Svensson

Phillips

McCall McCall

Piercey Piercey

Smith Smith

Svensson

Carlsson

Chidester

Von Voigtlander

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Article abstract of DOI:10.1021/jm00067a018

The synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b- hexahydro-3-propyl-1H-benz-[e]indole-9-carboxamide ((-)-3a), U93385, is described. The cis racemate and its enantiomer as well as the corresponding trans enantiomers were also synthesiz

Full text of DOI:10.1021/jm00067a018

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