Diversity-oriented approach to novel spirocyclics via enyne metathesis, diels-alder reaction, and a [2+2+2] cycloaddition as key steps

Article abstract of DOI:10.1055/s-0033-1339489

A simple protocol for the synthesis of indane-based spirocyclics has been developed via enyne metathesis, Diels-Alder reaction, and a [2+2+2] cycloaddition as key steps starting from indane-1,3-dione. The key diene building block was assembled by enyne metathesis. In this sequence, rongalite is used as a green reagent to prepare the sultine intermediate, which is a useful precursor to generate the transient diene.