Diastereoselective synthesis and optical resolution of 3,4-substituted tetrahydroisoquinolin-4-ols

DOI: 10.1016/S0040-4020(01)86282-7

Source and publish data:

Tetrahedron p. 1017 - 1024 (1993)

Update date:2022-08-03

Topics:

Authors:

Kihara, Masaru

Ikeuchi, Motoki

Jinno, Kaori

Kashimoto, Minoru

Kobayashi, Yoshimaro

Nagao, Yoshimitsu

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Article abstract of DOI:10.1016/S0040-4020(01)86282-7

Trans-3,4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared diastereoselectively by an insertion reaction with zerovalent nickel and by Barbier reaction with butyllithium of N-(2-iodobenzyl)phenacylamines. The isoquinolin-4-ols were resolved by means of HPLC method and the absolute configurations were determined.

Full text of DOI:10.1016/S0040-4020(01)86282-7

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