Renin inhibitors. II. Synthesis and structure-activity relationships of N-terminus modified inhibitors containing a homostatine analogue

DOI: 10.1248/cpb.40.3214

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3214 - 3221 (1992)

Update date:2022-08-03

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Authors:

Atsuumi Atsuumi

Nakano Nakano

Koike Koike

Tanaka Tanaka

Funabashi

Matsuyama

Nakano Nakano

Sawasaki

Funabashi

Morishima

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Article abstract of DOI:10.1248/cpb.40.3214

The synthesis and structure-activity relationships of N-terminus modified renin inhibitors containing the homostatine analogue, (2RS,4S,5S)-5-amino-2-ethyl-4-hydroxy-7-methyloctanoic acid, are described. The compounds having a 3-alkyl (or aryl)sulfonylpro

Full text of DOI:10.1248/cpb.40.3214

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