Synthesis and modification of a novel 1 β-methyl carbapenem antibiotic, S-4661

DOI: 10.7164/antibiotics.49.478

Source and publish data:

Journal of Antibiotics p. 478 - 484 (1996)

Update date:2022-08-04

Topics:

Authors:

Iso Iso

Irie Irie

Iwaki Iwaki

Kii Kii

Sendo Sendo

Motokawa

Nishitani

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Article abstract of DOI:10.7164/antibiotics.49.478

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.

Full text of DOI:10.7164/antibiotics.49.478

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Product name:(2S,4S)-tert-butyl 4-(acetylthio)-2-((tert-butoxycarbonyl(sulfaMoyl)aMino)Methyl)pyrrolidine-1-carboxylate

Cas No:148017-43-0

R&D Labs maybe for 148017-43-0

Junkai (Tianjin) Chemical Co., Ltd.

website:http://www.junkaichem.com

Contact:86-22-85689515

Address:Room 8-501, Building K2, The Hi-Tech Green Industrial Base, No.6, 6th Road, Hi-Tech Development Road, Tianjin Hi-Tech IndustrialPark, Tianjin, China.
Nanjing Zelang Medical Technology Co. Ltd

Contact:86-25-83063290/13770714480

Address:Ganjiabian 108# 01 Unit,701-702 room,Yao Hua Street,Qixia District,Nanjing,Jiangsu,China
Nanjing yieldpharma co.ltd

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Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Hangzhou Haiqiang Chemical Co.,Ltd.

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BAODING SINO-CHEM INDUSTRY CO.,LTD

Contact:0312-5956088

Address:NO.8 FUXING ROAD,CHINA

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