Synthesis and modification of a novel 1 β-methyl carbapenem antibiotic, S-4661

DOI: 10.7164/antibiotics.49.478

Source and publish data:

Journal of Antibiotics p. 478 - 484 (1996)

Update date:2022-08-04

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Authors:

Iso Iso

Irie Irie

Iwaki Iwaki

Kii Kii

Sendo Sendo

Motokawa

Nishitani

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Article abstract of DOI:10.7164/antibiotics.49.478

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.

Full text of DOI:10.7164/antibiotics.49.478

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Product name:(2S,4S)-tert-butyl 4-(acetylthio)-2-((tert-butoxycarbonyl(sulfaMoyl)aMino)Methyl)pyrrolidine-1-carboxylate

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