A stereocontrolled method for the synthesis of each of the four diastereomers of 34-dialkyl-substituted β-lactams using different metal ester enolates and a chiral imine

Article abstract of DOI:10.1016/S0040-4039(00)91781-7

The reaction of the different metal ester enolates of t-butyl α-alkyl substituted acetates with a chiral imine possessing a dioxolane ring derived from (2S,3S)-1,4-dimethoxy-2,3-butanediol as a chiral auxiliary followed by cyclization of the initial produ