Journal of the Chemical Society. Perkin transactions I p. 731 - 736 (1993)
Update date:2022-08-03
Topics:
Singh, Harjit
Singh, Palwinder
Aggarwal, Pawan
Kumar, Subodh
6-Methyl-1,3-oxazine-2,4(3H)-dione 1 reacts with 2 equiv. arylamines 3 at 150-160 deg C to give 1-aryl-6-methyluracils 5 or 1-aryl-3-(3-aryliminobutanoyl)ureas 4.The latter - as well as mixtures of 1 and 3 (2 equiv.) on refluxing, in isopentanol in some cases or in acetic acid in general - provide a facile synthesis of 5.The role of the stoichiometric excess of arylamines as against an equiv. of an alkylamine in similar reactions has been rationalized.
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Doi:10.1016/S0040-4039(00)73890-1
(1993)Doi:10.1016/S0040-4020(01)80387-2
(1993)Doi:10.1039/c4ra07370c
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